Can BPC-157 Boost Endurance and Support Testosterone? Here’s What We Know

Whether you’re a cyclist grinding out miles, a CrossFitter chasing PRs, or a grappler pushing through marathon training sessions— endurance matters . And if you're trying to stay lean, energized, and recover fast, testosterone plays a big role too .

Now, there’s a growing interest in a peptide called BPC-157 , known for its injury recovery benefits—but recently, people are asking if it can help with performance, stamina, and hormonal support too.

So let’s unpack the science. Can BPC-157 really improve endurance and help support testosterone levels naturally? Or is it just another overhyped compound?

Quick refresher— BPC-157 (Body Protection Compound 157) is a peptide made of 15 amino acids, originally derived from a protective protein found in the stomach. It’s been studied extensively in animal models for:

• Healing tendons, muscles, and ligaments

• Protecting the gut lining

• Reducing inflammation

• Improving blood flow

But more recently, it’s getting attention for possible performance-enhancing benefits—especially in endurance, recovery, and hormonal balance .

Endurance isn’t just about how hard you can push—it’s about how well your body can oxygenate tissue, manage inflammation, and recover from fatigue .

Here’s how BPC-157 may support that:

One of BPC-157’s standout traits is its ability to stimulate angiogenesis —the creation of new blood vessels. This helps improve blood flow to muscles during and after activity, delivering more oxygen and clearing out metabolic waste.

More oxygen = more stamina. Less lactic acid = less burnout.

In a study published in Current Pharmaceutical Design, BPC-157 promoted vascular regeneration and healing of ischemic tissues , which could translate to improved tissue resilience during long-duration exercise [(Jere et al., 2013)].

Endurance athletes often deal with low-level inflammation that chips away at performance. BPC-157 appears to modulate pro-inflammatory cytokines and reduce oxidative stress , giving your body a cleaner internal environment to perform [(Sikiric et al., 2018)].

Less inflammation means:

• Less soreness after training

• Better muscle function during sustained output

• Faster bounce-back between sessions

Endurance isn’t just physical—it’s mental. BPC-157 has shown neuroprotective effects in animal models, helping the brain recover from stress, reduce fatigue, and maintain focus during long periods of strain [(Zorić et al., 2018)].

This is huge for competitive athletes who push through hours of training and need to stay sharp under pressure.

Now here’s where things get interesting.

There’s no direct human study showing that BPC-157 boosts testosterone levels, but in animal models, it’s been shown to protect and regenerate the testes after damage from stress or toxins.

In one study, rats exposed to testicular injury (including alcohol-induced damage) showed restoration of Leydig cells —the cells responsible for testosterone production—after treatment with BPC-157 [(Sikiric et al., 2010)].

Potential Benefits:

• Supports testicular function

• Protects testosterone-producing cells from oxidative stress

• May help maintain hormone levels under chronic physical stress

This could make BPC-157 a tool for:

• Men over 30 experiencing age-related T decline

• Athletes exposed to high training stress

• Individuals looking to optimize natural hormone balance without TRT

Most protocols follow cycles of 2–4 weeks, taken daily. Use cases include:

• During high-volume training blocks

• Post-competition recovery

• As part of a hormone optimization or anti-aging stack

Formulations come in:

• Oral capsules (easy to use, systemic benefits)

• Injectable form (more targeted, but requires needles)

It’s often paired with other supportive compounds like:

• TB-500 (for systemic healing)

• L-glutamine, creatine, or collagen (for muscle & gut synergy)

• Tongkat Ali or Fadogia Agrestis (for direct T support)

Animal studies suggest BPC-157 is extremely safe—even at high doses, no toxicity was observed [(Sikiric et al., 2018)]. No significant side effects have been reported anecdotally, but as always, it’s not FDA-approved and is sold as a research compound .

If you’re considering it, talk with a knowledgeable provider—especially if you’re also tracking hormone levels.

The research isn’t conclusive yet—but early evidence shows a strong case for BPC-157’s indirect benefits on both.

• Better blood flow = more endurance.

• Lower inflammation = better recovery.

• Testicular protection = more stable testosterone levels.

• CNS support = mental stamina during long sessions.

For guys pushing their limits—on the track, in the gym, or on the mats— BPC-157 may offer a legit edge in staying strong, lean, and hormonally balanced.

• Jere, S. W., et al. (2013). The healing-promoting properties of BPC 157 in vascular and soft tissue repair. Current Pharmaceutical Design.

• Sikiric, P., et al. (2010). BPC 157 and its protective effects on testicular and reproductive function in rats. Journal of Physiology and Pharmacology.

• Zorić, D., et al. (2018). Neuroprotective effects of BPC 157 in models of brain injury and stress. Life Sciences.